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Calibrators & Controls


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Calibrators & Controls

The range of calibrators and controls proposed allows standardizing the assays and validating the series.

They are established in accordance with International Standards from the National Institute for Biological Standards and Controls (NIBSC, Potters Bar, UK), when available.Calibrators and controls offer prolonged stability following reconstitution.

Calibrators and Controls for Clotting Assays

Heparin and Analogues

Non Titrated Human Plasmas (Normal)

Calibrators & Controls for Plasma Factors & Co-Factors

Lupus Anticoagulant (Plasma)

Direct Factor Xa Inhibitors (Rivaroxaban)

Controls for Enzyme Immuno-Assays

HYPHEN BioMed proposes various controls for peculiar hemostasis or Fibrinolysis proteins, or blood markers, which can be used with any enzyme Immuno-assay. Reactivity of the Immuno-assay used, and its calibration method, must be considered for adjusting the control value indicated, if required.

Calibrators and controls (two levels) are included in all the ELISA kits in the ZYMUTEST line. Separate control kits (two levels) are also included, which can be used in any Immuno-assay for the indicated parameter.

Controls for Enzyme Immuno-Assays

Heparin Kits and HIT Assays

ZYMUTEST HIA kits offer a range of immuno-assays designed for testing heparin dependent antibodies, involved in the development of Heparin Induced Thrombocytopenia (HIT) or Heparin Induced Thrombocytopenia and Thrombosis (HITT). ZYMUTEST HIA, IGAM (ARK040D) measures the total antibodies, offering the highest sensitivity as all isotypes are detected. It is the preferred assay when an early detection of heparin dependent antibodies is required for assessing the development risk of HIT/HITT. ZYMUTEST HIA, IgG (ARK040A) measures only the IgG isotype, which is reported as being the most associated with the clinical complications of heparin dependent antibodies (HIT/HITT), allowing confirmation of the diagnosis of HIT/HITT or its clinical suspicion. However, some cases associated with only IgM and/or IgA isotypes can be missed. ZYMUTEST HIA, IgG, IgM and IgA (ARK040E) is designed for the full isotyping of heparin dependent antibodies, applications to characterize isotype distribution in patients with a risk or a suspicion of HIT/HITT, or for research investigations.

Diagnosis of Heparin Induced Thrombocytopenia (HIT)



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